Crosses indicate metabolic flux blocked by gene inactivation or deletion. Thicker lines indicate introduction and/or increase of the metabolic flux by gene over-expression. Dephosphorylation and secretion of N-acetylglucosamine-6-P are indicated by a dotted line. Gln: glutamine, GlcN: glucosamine, GlcNAc: N-acetylglucosamine.
Abbreviations for Genes:
- ptsG: glucose transporter
- nagE: N-acetylglucosamine transporter
- manXYZ: mannose transporter (also transports GlcN and GlcNAc)
- pgi: phosphoglucoisomerase
- pfk: phosphofructokinase
- glmS: glucosamine synthase
- nagB: glucosamine-6-P deaminase
- nagA: N-acetylglucosamine-6-P deacetylase
- GNA1: glucosamine N-acetyltransferase
- glmM: phosphoglucosamine mutase
- glmU: glucosamine-1-P acetyltransferase/N-acetylglucosamine-1-P uridyltransferase